Melanoma Genome Sequence Shows PREX2 as a Significantly Mutated Gene
Berger, Hodis et al., Nature
A team led by investigators at the Broad Institute reports having sequenced the genomes of 25 metastatic melanomas and matched germline DNA, through which it identified a "wide range of point mutation rates," and PREX2 as a significantly mutated gene in melanomas.
Future of the Force
A new report from the National Institutes of Health Advisory Committee to the Director reviews feedback the group received following its request for information on the future of the biomedical workforce. Sally Rockey, deputy director of extramural research at NIH, sums up the report, noting at her blog that "questions of supply and demand and characteristics of the PhD received the most comments." The report, which is based on 219 comments, also offers recommendations. To address the concern of supply and demand, the report advises decreasing the number of supported students and postdocs while increasing funding. Then to deal with PhD characteristics, it recommends changing how NIH supports PhDs, providing funding for career development programs that include alternative career advice, and modifying grant review policies so that having trainees who go on to work outside academia are not termed "training failures."